Structure of PDB 5n7v Chain A

Receptor sequence
>5n7vA (length=261) Species: 9606 (Homo sapiens) [Search protein sequence]
QSMSVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTL
DSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKK
KKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDF
GIANQMQPDSQVGTVNYMPPEAIKDMKISPKSDVWSLGCILYYMTYGKTP
FQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIP
ELLAHPYVQIQ
3D structure
PDB5n7v Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity.
ChainA
Resolution2.52 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D647 K649 N652 D664 T686
Catalytic site (residue number reindexed from 1) D132 K134 N137 D149 T164
Enzyme Commision number 2.7.12.1: dual-specificity kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8PT A I531 V539 A551 I586 C604 G605 L654 P673 I16 V24 A36 I71 C89 G90 L139 P158 PDBbind-CN: -logKd/Ki=8.77,Kd=1.7nM
BindingDB: IC50=1.8nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5n7v, PDBe:5n7v, PDBj:5n7v
PDBsum5n7v
PubMed28539250
UniProtP33981|TTK_HUMAN Dual specificity protein kinase TTK (Gene Name=TTK)

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