Structure of PDB 5n6i Chain A

Receptor sequence
>5n6iA (length=357) Species: 10090 (Mus musculus) [Search protein sequence]
KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRGNPL
SHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLI
RNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLV
PKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECL
KLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSC
FDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERN
NGFPIFD
3D structure
PDB5n6i cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders.
ChainA
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A S165 N172 Y200 K372 S17 N24 Y52 K224
BS02 dna A R158 K160 R161 R180 H203 K395 R10 K12 R13 R32 H55 K247
BS03 dna A K315 R342 K167 R194
BS04 dna A P243 T334 K335 T338 P95 T186 K187 T190
BS05 ZN A H378 C384 C385 C392 H230 C236 C237 C244
External links
PDB RCSB:5n6i, PDBe:5n6i, PDBj:5n6i
PDBsum5n6i
PubMed28902841
UniProtQ8C6L5|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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