Structure of PDB 5n2r Chain A

Receptor sequence
>5n2rA (length=388) Species: 562,9606 [Search protein sequence]
GAPPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSL
AAADILVGVLAIPFAITISTGFCAACHGCLFIACFVLVLAQSSIFSLLAI
AIDRYIAIAIPLRYNGLVTGTRAAGIIAICWVLSFAIGLTPMLGWNNCGQ
PKEGKAHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYL
RIFAAARRQLADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDA
QKATDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKY
LERARSTLQKEVHAAKSAAIIAGLFALCWLPLHIINCFTFFCPDCSHAPL
WLMYLAIVLAHTNSVVNPFIYAYRIREFRQTFRKIIRS
3D structure
PDB5n2r Structures of Human A1 and A2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8JN A F168 M174 W246 L249 N253 T256 H264 M270 I274 H278 F170 M176 W329 L332 N336 T339 H347 M353 I357 H361
BS02 CLR A A72 G76 I80 A74 G78 I82
BS03 CLR A P248 I252 S263 L269 P331 I335 S346 L352
BS04 CLR A C254 F255 F258 C259 C337 F338 F341 C342
Gene Ontology
Molecular Function
GO:0001609 G protein-coupled adenosine receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0001973 G protein-coupled adenosine receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0022900 electron transport chain
Cellular Component
GO:0016020 membrane
GO:0042597 periplasmic space

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Cellular Component
External links
PDB RCSB:5n2r, PDBe:5n2r, PDBj:5n2r
PDBsum5n2r
PubMed28712806
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P29274|AA2AR_HUMAN Adenosine receptor A2a (Gene Name=ADORA2A)

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