Structure of PDB 5n21 Chain A

Receptor sequence
>5n21A (length=122) Species: 9606 (Homo sapiens) [Search protein sequence]
SQIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGL
FYSIFTDQLKRNLSVINLDPEINPEGFNILLDFMYTSRLNLREGNIMAVM
ATAMYLQMEHVVDTCRKFIKAS
3D structure
PDB5n21 Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.
ChainA
Resolution1.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8HN A M51 C53 G55 Y58 Q113 E115 M45 C47 G49 Y52 Q107 E109 MOAD: Kd=1.1uM
PDBbind-CN: -logKd/Ki=5.96,Kd=1.1uM
BindingDB: Kd=1100nM
BS02 8HN A N21 R24 L25 N15 R18 L19 MOAD: Kd=1.1uM
PDBbind-CN: -logKd/Ki=5.96,Kd=1.1uM
BindingDB: Kd=1100nM
External links
PDB RCSB:5n21, PDBe:5n21, PDBj:5n21
PDBsum5n21
PubMed28485934
UniProtP41182|BCL6_HUMAN B-cell lymphoma 6 protein (Gene Name=BCL6)

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