Structure of PDB 5n1z Chain A

Receptor sequence
>5n1zA (length=123) Species: 9606 (Homo sapiens) [Search protein sequence]
DSQIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSG
LFYSIFTDQLKRNLSVINLDPEINPEGFNILLDFMYTSRLNLREGNIMAV
MATAMYLQMEHVVDTCRKFIKAS
3D structure
PDB5n1z Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.
ChainA
Resolution1.81 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8GQ A M51 A52 G55 Y58 Q113 M114 E115 M46 A47 G50 Y53 Q108 M109 E110 MOAD: Kd=0.0065uM
PDBbind-CN: -logKd/Ki=8.19,Kd=0.0065uM
BindingDB: IC50=1995nM
External links
PDB RCSB:5n1z, PDBe:5n1z, PDBj:5n1z
PDBsum5n1z
PubMed28485934
UniProtP41182|BCL6_HUMAN B-cell lymphoma 6 protein (Gene Name=BCL6)

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