Structure of PDB 5n16 Chain A

Receptor sequence
>5n16A (length=129) Species: 5476 (Candida albicans) [Search protein sequence]
GAPKPPQEPDMNNLPENPIPQHQAKFVLNTIKAVKRNREAVPFLHPVDTV
KLNVPFYYNYIPRPMDLSTIERKINLKAYEDVSQVVDDFNLMVKNCKKFN
GEAAGISKMATNIQAQFEKLMVKVPPKEL
3D structure
PDB5n16 Selective BET bromodomain inhibition as an antifungal therapeutic strategy.
ChainA
Resolution1.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8FN A P233 F234 V238 C287 F290 N291 I297 P42 F43 V47 C96 F99 N100 I106 MOAD: Kd=5uM
PDBbind-CN: -logKd/Ki=5.30,Kd=5uM
BS02 8FN A D239 K242 L243 D48 K51 L52 MOAD: Kd=5uM
PDBbind-CN: -logKd/Ki=5.30,Kd=5uM
External links
PDB RCSB:5n16, PDBe:5n16, PDBj:5n16
PDBsum5n16
PubMed28516956
UniProtQ5A4W8|BDF1_CANAL Bromodomain-containing factor 1 (Gene Name=BDF1)

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