Structure of PDB 5myr Chain A

Receptor sequence
>5myrA (length=193) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
GDDRELAILATAENLLEDRPLADISVDDLAKGAGISRPTFYFYFPSKEAV
LLTLLDRVVNQADMALQTLAENPADTDRENMWRTGINVFFETFGSHKAVT
RAGQAARATSVEVAELWSTFMQKWIAYTAAVIDAERDRGAAPRTLPAHEL
ATALNLMNERTLFASFAGEQPSVPEARVLDTLVHIWVTSIYGE
3D structure
PDB5myr Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach.
ChainA
Resolution1.828 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UDY A W103 G106 I107 F110 F114 W138 M142 W145 Y148 T149 N176 E180 L183 F184 W207 W82 G85 I86 F89 F93 W117 M121 W124 Y127 T128 N155 E159 L162 F163 W186 MOAD: ic50=22uM
PDBbind-CN: -logKd/Ki=4.66,IC50=22uM
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045892 negative regulation of DNA-templated transcription
GO:0046677 response to antibiotic
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:5myr, PDBe:5myr, PDBj:5myr
PDBsum5myr
PubMed29018348
UniProtP9WMC1|ETHR_MYCTU HTH-type transcriptional regulator EthR (Gene Name=ethR)

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