Structure of PDB 5my8 Chain A

Receptor sequence
>5my8A (length=355) Species: 9606 (Homo sapiens) [Search protein sequence]
KGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKS
AEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICM
VFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTD
IKPENILLSVNEQYIRRLAAEATEWQRFLVNPLEPKNAEKLKVKIADLGN
ACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYL
FEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHI
TKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRH
PWLNS
3D structure
PDB5my8 Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D213
Catalytic site (residue number reindexed from 1) D150
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RXZ A W88 S92 V94 A107 K109 F165 V167 L168 G169 H170 L220 V223 Y227 A496 W25 S29 V31 A44 K46 F102 V104 L105 G106 H107 L157 V160 Y164 A196 MOAD: Kd=72nM
PDBbind-CN: -logKd/Ki=7.14,Kd=72nM
BindingDB: IC50=3.18nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5my8, PDBe:5my8, PDBj:5my8
PDBsum5my8
PubMed28135068
UniProtQ96SB4|SRPK1_HUMAN SRSF protein kinase 1 (Gene Name=SRPK1)

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