Structure of PDB 5mxx Chain A

Receptor sequence
>5mxxA (length=361) Species: 9606 (Homo sapiens) [Search protein sequence]
QEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKF
VAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISG
VNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHT
KCRITHTDIKPENILLSVNEQYIRRLAAEATENFLVNPLEPKNAEKLKVK
IADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFEL
ATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKK
GDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATA
AECLRHPWLNS
3D structure
PDB5mxx Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease.
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D213
Catalytic site (residue number reindexed from 1) D158
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 W4A A L86 A107 F165 V167 L168 G169 H170 L220 Y227 L31 A52 F110 V112 L113 G114 H115 L165 Y172 MOAD: ic50=31nM
PDBbind-CN: -logKd/Ki=7.51,IC50=31nM
BindingDB: IC50=31nM
BS02 CA A E614 E617 E320 E323
BS03 CA A E610 E614 E316 E320
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5mxx, PDBe:5mxx, PDBj:5mxx
PDBsum5mxx
PubMed28135068
UniProtQ96SB4|SRPK1_HUMAN SRSF protein kinase 1 (Gene Name=SRPK1)

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