Structure of PDB 5mwz Chain A

Receptor sequence
>5mwzA (length=114) Species: 9606 (Homo sapiens) [Search protein sequence]
MEMQLTPFLILLRKTLEQLQEKDTGNIFSEPVPLSEVPDYLDHIKKPMDF
FTMKQNLEAYRYLNFDDFEEDFNLIVSNCLKYNAKDTIFYRAAVRLREQG
GAVLRQARRQAEKM
3D structure
PDB5mwz Structure-based discovery of selective BRPF1 bromodomain inhibitors.
ChainA
Resolution1.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KGU A I652 F653 V657 P658 C704 Y707 N708 F714 I27 F28 V32 P33 C79 Y82 N83 F89 MOAD: Kd=7.1uM
PDBbind-CN: -logKd/Ki=5.15,Kd=7.1uM
External links
PDB RCSB:5mwz, PDBe:5mwz, PDBj:5mwz
PDBsum5mwz
PubMed29902720
UniProtP55201|BRPF1_HUMAN Peregrin (Gene Name=BRPF1)

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