Structure of PDB 5mwy Chain A

Receptor sequence
>5mwyA (length=244) Species: 9606 (Homo sapiens) [Search protein sequence]
YFSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQVVKWA
KVLPGFKNLPLEDQITLIQYSWMSLSSFALSWRSYKHTNSQFLYFAPDLV
FNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKD
GLKSQAAFEEMRTNYIKELRKMVTGQSWQRFYQLTKLLDSMHDLVSDLLE
FCFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYFHRK
3D structure
PDB5mwy Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion.
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V781 K785 L795 I799 A958 E962 V47 K51 L61 I65 A218 E222
BS02 YNU A L766 L769 N770 Q776 W806 M807 S810 L814 F829 M845 M852 L938 F941 C942 T945 F956 L32 L35 N36 Q42 W72 M73 S76 L80 F95 M111 M118 L198 F201 C202 T205 F216 MOAD: Ki=100nM
PDBbind-CN: -logKd/Ki=7.00,Ki=100nM
BindingDB: IC50=122nM,EC50=100nM,Ki=126nM
External links
PDB RCSB:5mwy, PDBe:5mwy, PDBj:5mwy
PDBsum5mwy
PubMed29474466
UniProtP08235|MCR_HUMAN Mineralocorticoid receptor (Gene Name=NR3C2)

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