Structure of PDB 5mwp Chain A

Receptor sequence
>5mwpA (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]
YFSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQVVKWA
KVLPGFKNLPLEDQITLIQYSWMSLSSFALSWRSYKHTNSQFLYFAPDLV
FNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKD
GLKSQAAFEEMRTNYIKELRKMVTKSWQRFYQLTKLLDSMHDLVSDLLEF
CFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYFHRK
3D structure
PDB5mwp Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion.
ChainA
Resolution1.82 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V781 K785 L795 I799 A958 E962 V47 K51 L61 I65 A217 E221
BS02 ECV A N770 L772 A773 Q776 M807 S810 S811 L814 F829 M845 M852 L938 F941 C942 T945 N36 L38 A39 Q42 M73 S76 S77 L80 F95 M111 M118 L197 F200 C201 T204 MOAD: Ki=31.6nM
PDBbind-CN: -logKd/Ki=7.50,Ki=31.6nM
BindingDB: IC50=<10000nM,Ki=40nM,EC50=13nM
External links
PDB RCSB:5mwp, PDBe:5mwp, PDBj:5mwp
PDBsum5mwp
PubMed29474466
UniProtP08235|MCR_HUMAN Mineralocorticoid receptor (Gene Name=NR3C2)

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