Structure of PDB 5mwj Chain A

Receptor sequence
>5mwjA (length=324) Species: 9606 (Homo sapiens) [Search protein sequence]
YFQGAMGSKPAYSFHVTQMQPVPFPPDALIGPGIPRHARQINTLNHGEVV
CAVTISNPTRHVYTGGKGCVKVWDISSPVSQLDCLNRDNYIRSCKLLPDG
CTLIVGGEASTLSIWDLPRIKAELTSSAPACYALAISPDSKVCFSCCSDG
NIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLR
EGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHL
HESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCD
ISVDDKYIVTGSGDKKATVYEVIY
3D structure
PDB5mwj Structure-Enabled Discovery of a Stapled Peptide Inhibitor to Target the Oncogenic Transcriptional Repressor TLE1.
ChainA
Resolution2.04 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EBU A C488 Y532 R534 E550 A576 Y578 L636 F661 L743 C51 Y90 R92 E108 A130 Y132 L190 F215 L297 MOAD: Kd=24.7nM
PDBbind-CN: -logKd/Ki=7.61,Kd=24.7nM
Gene Ontology
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:5mwj, PDBe:5mwj, PDBj:5mwj
PDBsum5mwj
PubMed28326635
UniProtQ04724|TLE1_HUMAN Transducin-like enhancer protein 1 (Gene Name=TLE1)

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