Structure of PDB 5mwg Chain A

Receptor sequence
>5mwgA (length=110) Species: 9606 (Homo sapiens) [Search protein sequence]
LTPFLILLRKTLEQLQEKDTGNIFSEPVPLSEVPDYLDHIKKPMDFFTMK
QNLEAYRYLNFDDFEEDFNLIVSNCLKYNAKDTIFYRAAVRLREQGGAVL
RQARRQAEKM
3D structure
PDB5mwg Structure-based discovery of selective BRPF1 bromodomain inhibitors.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WGX A F653 V657 P658 E661 Y707 N708 F714 F24 V28 P29 E32 Y78 N79 F85 MOAD: ic50=1.7uM
PDBbind-CN: -logKd/Ki=5.77,IC50=1.7uM
BindingDB: IC50=1700nM
External links
PDB RCSB:5mwg, PDBe:5mwg, PDBj:5mwg
PDBsum5mwg
PubMed29902720
UniProtP55201|BRPF1_HUMAN Peregrin (Gene Name=BRPF1)

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