Structure of PDB 5mw8 Chain A

Receptor sequence

>5mw8A (length=414) Species: 10090 (Mus musculus)

KMDENEWSYHGEGNKSLVVAHAQRCVVLRFLKFPPNKTSEEILQHLQNIV
DFGKNVMKDFLGENYVHCGEVVQLPLEFVKQLCLKIQCERPESRCDKDLD
TFSGYAMCLPNLTRLHRPILCVEIKPKCGFIPFSNDVTHEMKHKVCRYCM
HQHLKVATGKWKKISKYCPLDLYSGNKQRMHFALRSLLQETQNNLRIFKN
GELIYGCDLKELAHHLKPFFFPSGPHCTKAVIRELVHVITRVLLSSSEKA
RAGALRLGLQGPRVCEASPSGLPKGCLLYKTLQVQMLDQLDIEGLYPLYK
RVEQYLEEFPEERKTLQIDGPYDEVFYQKLLDLSTEDDGTVAFALTKVQQ
YRVAMTAKDCSIMIALSPCPVIPSSRSRLAFSVSVLDLDLKPYESIPHQY
KLDSKIVNYYSKTV

3D structure

• PDB: 5mw8 The crystal structure of mammalian inositol 1,3,4,5,6-pentakisphosphate 2-kinase reveals a new zinc-binding site and key features for protein function.
• Chain: A
• Resolution: 2.4 Å

Enzymatic activity

• Enzyme Commision number: 2.7.1.158: inositol-pentakisphosphate 2-kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ATP	A	H14 E16 G17 K19 S20 V22 V31 R33 P116 N117 L118 E136 K138 L436 D437	H10 E12 G13 K15 S16 V18 V27 R29 P110 N111 L112 E123 K125 L386 D387
BS02	5MY	A	N18 K19 R100 K138 K140 K168 N206 D400 K441 Q449	N14 K15 R94 K125 K127 K155 N193 D359 K391 Q399
BS03	ZN	A	C159 C162 C181 C291	C146 C149 C168 C265

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016301 kinase activity
• GO:0035299 inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity

Biological Process

• GO:0016310 phosphorylation

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm

External links

• PDB: RCSB:5mw8, PDBe:5mw8, PDBj:5mw8
• PDBsum: 5mw8
• PubMed: 28450399
• UniProt: Q6P1C1|IPPK_MOUSE Inositol-pentakisphosphate 2-kinase (Gene Name=Ippk)