Structure of PDB 5msw Chain A

Receptor sequence
>5mswA (length=715) Species: 679197 (Segniliparus rugosus ATCC BAA-974) [Search protein sequence]
QSLAERVARLVAIDPQAAAAVPDKAVAERATQQGLRLAQRIEAFLSGYGD
RPALAQRAFEITKDPTGRAVATLLPKFETVSYRELLERSHAIASELANHA
EAPVKAGEFIATIGFTSTDYTSLDIAGVLLGLTSVPLQTGATTDTLKAIA
EETAPAVFGASVEHLDNAVTTALATPSVRRLLVFDYRQGVDEDREAVEAA
RSRLAEAGSAVLVDTLDEVIARGRALPRVALPPATDAGDDSLSLLIYTST
PKGAMYPERNVAQFWGGIWHNAFPDVPDIMVNFMPLSHVAGRIGLMGTLS
SGGTTYFIAKSDLSTFFEDYSLARPTKLFFVPRICEMIYQHYQSELDRIG
AADGSPQAEAIKTELREKLLGGRVLTAGSGSAPMSPELTAFIESVLQVHL
VDGYGSTEAGPVWRDRKLVKPPVTEHKLIDVPELGYFSTDSPYPRGELAI
KTQTILPGYYKRPETTAEVFDEDGFYLTGDVVAEVAPEEFVYVDRRKNVL
KLSQGEFVALSKLEAAYGTSPLVRQISVYGSSQRSYLLAVVVPTPEALAK
YGDGEAVKSALGDSLQKIAREEGLQSYEVPRDFIIETDPFTIENGILSDA
GKTLRPKVKARYGERLEALYAQLAETQAGELRSIRVGAGERPVIETVQRA
AAALLGASAAEVDPEAHFSDLGGDSLSALTYSNFLHEIFQVEVPVSVIVS
AANNLRSVAAHIEKE
3D structure
PDB5msw Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis.
ChainA
Resolution2.33 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) T265 F285 H315 T434 L529 K629
Catalytic site (residue number reindexed from 1) T248 F264 H288 T407 L502 K602
Enzyme Commision number 1.2.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A S408 A409 P410 G430 Y431 G432 T434 D507 Y519 R522 S381 A382 P383 G403 Y404 G405 T407 D480 Y492 R495
Gene Ontology
Molecular Function
GO:0004467 long-chain fatty acid-CoA ligase activity
GO:0005524 ATP binding
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0031177 phosphopantetheine binding
GO:0050661 NADP binding
Biological Process
GO:0001676 long-chain fatty acid metabolic process
GO:0006629 lipid metabolic process
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5msw, PDBe:5msw, PDBj:5msw
PDBsum5msw
PubMed28719588
UniProtE5XP76|CAR_SEGRC Carboxylic acid reductase (Gene Name=car)

[Back to BioLiP]