Structure of PDB 5mst Chain A

Receptor sequence
>5mstA (length=631) Species: 679197 (Segniliparus rugosus ATCC BAA-974) [Search protein sequence]
QSLAERVARLVAIDPQAAAAVPDKAVAERATQQGLRLAQRIEAFLSGYGD
RPALAQRAFEITKDPITGRAVATLLPKFETVSYRELLERSHAIASELANH
AEAPVKAGEFIATIGFTSTDYTSLDIAGVLLGLTSVPLQTGATTDTLKAI
AEETAPAVFGASVEHLDNAVTTALATPSVRRLLVFDYRQGVDEDREAVEA
ARSRLAEAGSAVLVDTLDEVIARGRALPRVALPPATDAGDDSLSLLIYTS
TPKGAMYPERNVAQFWGGIWHNAFDDGDSAPDVPDIMVNFMPLSHVAGRI
GLMGTLSSGGTTYFIAKSDLSTFFEDYSLARPTKLFFVPRICEMIYQHYQ
SELDRIGAADGSPQAEAIKTELREKLLGGRVLTAGSGSAPMSPELTAFIE
SVLQVHLVDGYGSTEAGPVWRDRKLVKPPVTEHKLIDVPELGYFSTDSPY
PRGELAIKTQTILPGYYKRPETTAEVFDEDGFYLTGDVVAEVAPEEFVYV
DRRKNVLKLSQGEFVALSKLEAAYGTSPLVRQISVYGSSQRSYLLAVVVP
TPEALAKYGDGEAVKSALGDSLQKIAREEGLQSYEVPRDFIIETDPFTIE
NGILSDAGKTLRPKVKARYGERLEALYAQLA
3D structure
PDB5mst Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis.
ChainA
Resolution1.72 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T265 F285 H315 T434 L529 K629
Catalytic site (residue number reindexed from 1) T249 F265 H295 T414 L509 K609
Enzyme Commision number 1.2.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A Y203 D234 Y187 D218
BS02 CA A A494 F497 A474 F477
BS03 FUM A F294 S408 G432 S433 P438 F274 S388 G412 S413 P418
BS04 AMP A H315 S408 A409 P410 G430 Y431 G432 S433 T434 D507 Y519 R522 K629 H295 S388 A389 P390 G410 Y411 G412 S413 T414 D487 Y499 R502 K609
Gene Ontology
Molecular Function
GO:0004467 long-chain fatty acid-CoA ligase activity
GO:0005524 ATP binding
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0031177 phosphopantetheine binding
GO:0050661 NADP binding
Biological Process
GO:0001676 long-chain fatty acid metabolic process
GO:0006629 lipid metabolic process
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5mst, PDBe:5mst, PDBj:5mst
PDBsum5mst
PubMed28719588
UniProtE5XP76|CAR_SEGRC Carboxylic acid reductase (Gene Name=car)

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