Structure of PDB 5mss Chain A

Receptor sequence
>5mssA (length=717) Species: 679197 (Segniliparus rugosus ATCC BAA-974) [Search protein sequence]
QSLAERVARLVAIDPQAAAAVPDKAVAERATQQGLRLAQRIEAFLSGYGD
RPALAQRAFEITKDPITGRAVATLLPKFETVSYRELLERSHAIASELANH
AEAPVKAGEFIATIGFTSTDYTSLDIAGVLLGLTSVPLQTGATTDTLKAI
AEETAPAVFGASVEHLDNAVTTALATPSVRRLLVFDYRQGVDEDREAVEA
ARSRLAEAGSAVLVDTLDEVIARGRALPRVALPPATDAGDDSLSLLIYTS
GSTGTPKGAMYPERNVAQFWGGIWHNAFDPDVPDIMVNFMPLSHVAGRIG
LMGTLSSGGTTYFIAKSDLSTFFEDYSLARPTKLFFVPRICEMIYQHYQS
ELDRIGAADGSPQAEAIKTELREKLLGGRVLTAGSGSAPMSPELTAFIES
VLQVHLVDGYGSTEAGPVWRDRKLVKPPVTEHKLIDVPELGYFSTDSPYP
RGELAIKTQTILPGYYKRPETTAEVFDEDGFYLTGDVVAEVAPEEFVYVD
RRKNVLKLSQGEFVALSKLEAAYGTSPLVRQISVYGSSQRSYLLAVVVPT
PEALAKYGDGEAVKSALGDSLQKIAREEGLQSYEVPRDFIIETDPFTIEN
GILSDAGKTLRPKVKARYGERLEALYAQLAETQAGELRSIRVGERPVIET
VQRAAAALLGAVDPEAHFSDLGGDSLSALTYSNFLHEIFQVEVPVSVIVS
AANNLRSVAAHIEKERS
3D structure
PDB5mss Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis.
ChainA
Resolution1.96 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T265 F285 H315 T434 L529 K629
Catalytic site (residue number reindexed from 1) T249 F269 H294 T413 L508 K608
Enzyme Commision number 1.2.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A S408 A409 P410 D429 G430 Y431 G432 S433 T434 D507 Y519 K528 S387 A388 P389 D408 G409 Y410 G411 S412 T413 D486 Y498 K507
Gene Ontology
Molecular Function
GO:0004467 long-chain fatty acid-CoA ligase activity
GO:0005524 ATP binding
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0031177 phosphopantetheine binding
GO:0050661 NADP binding
Biological Process
GO:0001676 long-chain fatty acid metabolic process
GO:0006629 lipid metabolic process
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5mss, PDBe:5mss, PDBj:5mss
PDBsum5mss
PubMed28719588
UniProtE5XP76|CAR_SEGRC Carboxylic acid reductase (Gene Name=car)

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