Structure of PDB 5msq Chain A

Receptor sequence
>5msqA (length=631) Species: 204891 (Nocardia iowensis) [Search protein sequence]
RLQRRIAQLFAEDEQVKAARPLEAVSAAVSAPGMRLAQIAATVMAGYADR
PAAGQRAFELNTDDATGRTSLRLLPRFETITYRELWQRVGEVAAAWHHDP
ENPLRAGDFVALLGFTSIDYATLDLADIHLGAVTVPLQASAAVSQLIAIL
TETSPRLLASTPEHLDAAVECLLAGTTPERLVVFDYHPEDDDQRAAFESA
RRRLADAGSLVIVETLDAVRARGRDLPAAPLFVPDTDDDPLALLIYTSGS
TGTPKGAMYTNRLAATMWQGNSMLQGNSQRVGINLNYMPMSHIAGRISLF
GVLARGGTAYFAAKSDMSTLFEDIGLVRPTEIFFVPRVCDMVFQRYQSEL
DRRSVAGADLDTLDREVKADLRQNYLGGRFLVAVVGSAPLAAEMKTFMES
VLDLPLHDGYGSTEAGASVLLDNQIQRPPVLDYKLVDVPELGYFRTDRPH
PRGELLLKAETTIPGYYKRPEVTAEIFDEDGFYKTGDIVAELEHDRLVYV
DRRNNVLKLSQGEFVTVAHLEAVFASSPLIRQIFIYGSSERSYLLAVIVP
TDDALRGRDTATLKSALAESIQRIAKDANLQPYEIPRDFLIETEPFTIAN
GLLSGIAKLLRPNLKERYGAQLEQMYTDLAT
3D structure
PDB5msq Structure and mechanism of carboxylic acid reductase
ChainA
Resolution1.74 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) M275 H300 T421 L517 K616
Catalytic site (residue number reindexed from 1) M267 H292 T413 L509 K608
Enzyme Commision number 1.2.1.-
1.2.1.30: carboxylate reductase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A H300 S395 A396 P397 D416 G417 Y418 S420 T421 D495 Y507 R510 K616 H292 S387 A388 P389 D408 G409 Y410 S412 T413 D487 Y499 R502 K608
Gene Ontology
Molecular Function
GO:0004467 long-chain fatty acid-CoA ligase activity
GO:0005524 ATP binding
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0031177 phosphopantetheine binding
GO:0047683 aryl-aldehyde dehydrogenase (NADP+) activity
GO:0050661 NADP binding
Biological Process
GO:0001676 long-chain fatty acid metabolic process
GO:0006629 lipid metabolic process
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5msq, PDBe:5msq, PDBj:5msq
PDBsum5msq
PubMed
UniProtQ6RKB1|CAR_NOCIO Carboxylic acid reductase (Gene Name=car)

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