Structure of PDB 5msd Chain A

Receptor sequence
>5msdA (length=636) Species: 204891 (Nocardia iowensis) [Search protein sequence]
DSPDERLQRRIAQLFAEDEQVKAARPLEAVSAAVSAPGMRLAQIAATVMA
GYADRPAAGQRAFELNTDDATGRTSLRLLPRFETITYRELWQRVGEVAAA
WHHDPENPLRAGDFVALLGFTSIDYATLDLADIHLGAVTVPLQASAAVSQ
LIAILTETSPRLLASTPEHLDAAVECLLAGTTPERLVVFDYHPEDDDQRA
AFESARRRLADAGSLVIVETLDAVRARGRDLPAAPLFVPDTDDDPLALLI
YTSGSTGTPKGAMYTNRLAATMWQGNSMLQGNSQRVGINLNYMPMSHIAG
RISLFGVLARGGTAYFAAKSDMSTLFEDIGLVRPTEIFFVPRVCDMVFQR
YQSELDRRSVAGADLDTLDREVKADLRQNYLGGRFLVAVVGSAPLAAEMK
TFMESVLDLPLHDGYGSTEAGASVLLDNQIQRPPVLDYKLVDVPELGYFR
TDRPHPRGELLLKAETTIPGYYKRPEVTAEIFDEDGFYKTGDIVAELEHD
RLVYVDRRNNVLKLSQGEFVTVAHLEAVFASSPLIRQIFIYGSSERSYLL
AVIVPTDDALRGRDTATLKSALAESIQRIAKDANLQPYEIPRDFLIETEP
FTIANGLLSGIAKLLRPNLKERYGAQLEQMYTDLAT
3D structure
PDB5msd Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis.
ChainA
Resolution1.71 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) M275 H300 T421 L517 K616
Catalytic site (residue number reindexed from 1) M272 H297 T418 L514 K613
Enzyme Commision number 1.2.1.-
1.2.1.30: carboxylate reductase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A H300 S395 A396 P397 G417 Y418 T421 D495 Y507 R510 K616 H297 S392 A393 P394 G414 Y415 T418 D492 Y504 R507 K613
Gene Ontology
Molecular Function
GO:0004467 long-chain fatty acid-CoA ligase activity
GO:0005524 ATP binding
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0031177 phosphopantetheine binding
GO:0047683 aryl-aldehyde dehydrogenase (NADP+) activity
GO:0050661 NADP binding
Biological Process
GO:0001676 long-chain fatty acid metabolic process
GO:0006629 lipid metabolic process
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5msd, PDBe:5msd, PDBj:5msd
PDBsum5msd
PubMed28719588
UniProtQ6RKB1|CAR_NOCIO Carboxylic acid reductase (Gene Name=car)

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