Structure of PDB 5mrp Chain A

Receptor sequence
>5mrpA (length=209) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]
EKSVSVILLAGPKQYIPLLGQPIALYSFFTFSRMPEVKEIVVVCDPFFRD
IFEEYEESIDVDLSFAIPGKERQDSVYSGLQEIDVNSELVCIHDSARPLV
NTEDVEKVLKDGSAVGAAVLGVPAKATIKEVNSDSLVVKTLWEMQTPQVI
KPELLKKGFELVKSEGLAVTDDVSIVEYLKHPVYVSQGSYTNIKVTTPDD
LLLAERILS
3D structure
PDB5mrp Mechanism of Allosteric Inhibition of the Enzyme IspD by Three Different Classes of Ligands.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.60: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6BC A R157 Q158 I177 A203 Q238 V239 D262 V263 I265 V266 V273 R72 Q73 I92 A118 Q148 V149 D172 V173 I175 V176 V183 MOAD: ic50=3uM
PDBbind-CN: -logKd/Ki=5.52,Kd=3.0uM
BindingDB: IC50=35nM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0050518 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GO:0070567 cytidylyltransferase activity
Biological Process
GO:0008299 isoprenoid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5mrp, PDBe:5mrp, PDBj:5mrp
PDBsum5mrp
PubMed28686408
UniProtP69834|ISPD_ARATH 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic (Gene Name=ISPD)

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