Structure of PDB 5mrm Chain A

Receptor sequence
>5mrmA (length=211) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]
MEKSVSVILLAPKQYIPLLGQPIALYSFFTFSRMPEVKEIVVVCDPFFRD
IFEEYEESIDVDLSFAIPGKERQDSVYSGLQEIDVNSELVCIHDSARPLV
NTEDVEKVLKDGSAVGAAVLGVPAKATIKEVNSDSLVVKTKTLWEMQTPQ
VIKPELLKKGFELVKSEGLEVTDDVSIVEYLKHPVYVSQGSYTNIKVTTP
DDLLLAERILS
3D structure
PDB5mrm Mechanism of Allosteric Inhibition of the Enzyme IspD by Three Different Classes of Ligands.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.60: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Q9T A Q158 V161 I177 A203 Q238 V239 L245 S264 V266 Q73 V76 I92 A118 Q150 V151 L157 S176 V178 MOAD: ic50=9.3uM
PDBbind-CN: -logKd/Ki=5.03,Kd=9.3uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0050518 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GO:0070567 cytidylyltransferase activity
Biological Process
GO:0008299 isoprenoid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5mrm, PDBe:5mrm, PDBj:5mrm
PDBsum5mrm
PubMed28686408
UniProtP69834|ISPD_ARATH 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic (Gene Name=ISPD)

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