Structure of PDB 5mrk Chain A

Receptor sequence
>5mrkA (length=260) Species: 64320 (Zika virus) [Search protein sequence]
GETLGEKWKARLNQMSALEFYSYKKSGITEVCREEARRALKDGVATGGHA
VSRGSAKLRWLVERGYLQPYGKVIDLGCGRGGWSYYAATIRKVQEVKGYT
KGGPGHEEPMLVQSYGWNIVRLKSGVDVFHMAAEPCDTLLCDIGESSSSP
EVEEARTLRVLSMVGDWLEKRPGAFCIKVLCPYTSTMMETLERLQRRYGG
GLVRVPLSRNSTHEMYWVSGAKSNTIKSVSTTSQLLLGRMDGPRRPVKYE
EDVNLGSGTR
3D structure
PDB5mrk Structural basis of Zika virus methyltransferase inhibition by sinefungin.
ChainA
Resolution1.9 Å
3D
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SFG A S56 G58 G81 G86 W87 T104 K105 H110 E111 V130 D131 V132 F133 D146 S52 G54 G77 G82 W83 T100 K101 H106 E107 V126 D127 V128 F129 D142
Gene Ontology
Molecular Function
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5mrk, PDBe:5mrk, PDBj:5mrk
PDBsum5mrk
PubMed28357511
UniProtA0A024B7W1|POLG_ZIKVF Genome polyprotein

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