Structure of PDB 5mqx Chain A

Receptor sequence

>5mqxA (length=160) Species: 36385 (Venezuelan equine encephalitis virus (strain P676)) [Search protein sequence]

APSYHVVRGDIATATEGVIINAANSKGQPGGGVCGALYKKFPESFDLQPI
EVGKARLVKGAAKHIIHAVGPNFNKVSEVEGDKQLAEAYESIAKIVNDNN
YKSVAIPLLSTGIFSGNKDRLTQSLNHLLTALDTTDADVAIYCRDKKWEM
TLKEAVARRE

3D structure

PDB

5mqx Conformational plasticity of the VEEV macro domain is important for binding of ADP-ribose.

Chain

Resolution

N/A

3D
structure

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Enzymatic activity

Enzyme Commision number

2.1.1.-
2.7.7.-
2.7.7.19: polynucleotide adenylyltransferase.
2.7.7.48: RNA-directed RNA polymerase.
3.1.3.84: ADP-ribose 1''-phosphate phosphatase.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.1.74: mRNA 5'-phosphatase.
3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	APR	A	D10 I11 G30 G31 G32 V33 C34 I113 F114 R144 W148	D10 I11 G30 G31 G32 V33 C34 I113 F114 R144 W148	PDBbind-CN: -logKd/Ki=5.41,Kd=3.9uM

External links

PDB	RCSB:5mqx, PDBe:5mqx, PDBj:5mqx
PDBsum	5mqx
PubMed	30825649
UniProt	P36328\|POLN_EEVVP Polyprotein P1234

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