Structure of PDB 5mpn Chain A

Receptor sequence
>5mpnA (length=118) Species: 9606 (Homo sapiens) [Search protein sequence]
SMRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDI
VKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFC
SKLAEVFEQEIDPVMQSL
3D structure
PDB5mpn Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
ChainA
Resolution1.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YE5 A P1110 V1115 N1168 R1173 V1174 P32 V37 N90 R95 V96 MOAD: Kd=0.085uM
PDBbind-CN: -logKd/Ki=7.07,Kd=0.085uM
BindingDB: Kd=85nM,IC50=59nM
BS02 YE5 A M1095 E1099 Y1102 M17 E21 Y24 MOAD: Kd=0.085uM
PDBbind-CN: -logKd/Ki=7.07,Kd=0.085uM
BindingDB: Kd=85nM,IC50=59nM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5mpn, PDBe:5mpn, PDBj:5mpn
PDBsum5mpn
PubMed30258543
UniProtQ92793|CBP_HUMAN CREB-binding protein (Gene Name=CREBBP)

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