Structure of PDB 5mpk Chain A

Receptor sequence
>5mpkA (length=112) Species: 9606 (Homo sapiens) [Search protein sequence]
IFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPM
DLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAE
VFEQEIDPVMQS
3D structure
PDB5mpk Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0BC A L1109 P1110 Q1113 V1115 L1120 N1168 R1173 V1174 L26 P27 Q30 V32 L37 N85 R90 V91 MOAD: Kd=0.003uM
PDBbind-CN: -logKd/Ki=8.52,Kd=0.003uM
BindingDB: IC50=15nM,Kd=3.0nM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5mpk, PDBe:5mpk, PDBj:5mpk
PDBsum5mpk
PubMed30258543
UniProtQ92793|CBP_HUMAN CREB-binding protein (Gene Name=CREBBP)

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