Structure of PDB 5mpf Chain A

Receptor sequence
>5mpfA (length=196) Species: 9606 (Homo sapiens) [Search protein sequence]
NNFEYTLEASKSLRGDSTMTYLNKGQFYPITLKEVSKVRSVIMVVFAEDK
SREDQLRHWKYWHSRQHTAKQRCIDIADYKESFNTISNVEEIAYNAISFT
WDINDEAKVFISVNCLSTDFSSQKGVKGLPLNIQIDTYNNKPVHRAYCQI
KVFCDKGAERKIRDEERKQSKRMDITVFKPFIDLDTQPVLFIPDVH
3D structure
PDB5mpf Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family.
ChainA
Resolution2.918 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A T380 K389 F420 C421 R427 T118 K127 F153 C154 R160 PDBbind-CN: Kd=90nM
BS02 dna A Q385 K386 G387 R430 Q123 K124 G125 R163 PDBbind-CN: Kd=90nM
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II

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Molecular Function
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Biological Process
External links
PDB RCSB:5mpf, PDBe:5mpf, PDBj:5mpf
PDBsum5mpf
PubMed29309642
UniProtQ9NZI5|GRHL1_HUMAN Grainyhead-like protein 1 homolog (Gene Name=GRHL1)

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