Structure of PDB 5mmp Chain A

Receptor sequence
>5mmpA (length=191) Species: 83334 (Escherichia coli O157:H7) [Search protein sequence]
IKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEI
IVTIHADNSVSVQDDGRGIPTGIHPEEGVSAAEVIMTVLVGVSVVNALSQ
KLELVIQREGKIHRQIYEHGVPQAPLAVTGETEKTGTMVRFWPSLETFTN
VTEFEYEILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHYE
3D structure
PDB5mmp Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G3Z A N46 E50 V71 D73 R76 G77 I78 P79 I94 T165 N37 E41 V62 D64 R67 G68 I69 P70 I85 T137 MOAD: ic50=0.03uM
PDBbind-CN: -logKd/Ki=7.52,IC50=0.03uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:5mmp, PDBe:5mmp, PDBj:5mmp
PDBsum5mmp
PubMed28406299
UniProtP0AES7|GYRB_ECO57 DNA gyrase subunit B (Gene Name=gyrB)

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