Structure of PDB 5mmn Chain A

Receptor sequence
>5mmnA (length=205) Species: 83334 (Escherichia coli O157:H7) [Search protein sequence]
SSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHC
KEIIVTIHADNSVSVQDDGRGIPTGIHPEEGVSAAEVIMTVLNSYKVSGG
LHGVGVSVVNALSQKLELVIQREGKIHRQIYEHGVPQAPLAVTGETEKTG
TMVRFWPSLETFTNVTEFEYEILAKRLRELSFLNSGVSIRLRDKRDGKED
HFHYE
3D structure
PDB5mmn Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents.
ChainA
Resolution1.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 O54 A V43 N46 E50 V71 D73 I78 P79 I94 V37 N40 E44 V65 D67 I72 P73 I88 MOAD: ic50=0.125uM
PDBbind-CN: -logKd/Ki=6.70,IC50<0.2uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5mmn, PDBe:5mmn, PDBj:5mmn
PDBsum5mmn
PubMed28406299
UniProtP0AES7|GYRB_ECO57 DNA gyrase subunit B (Gene Name=gyrB)

[Back to BioLiP]