Structure of PDB 5mme Chain A

Receptor sequence
>5mmeA (length=119) Species: 9606 (Homo sapiens) [Search protein sequence]
SMRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDI
VKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFC
SKLAEVFEQEIDPVMQSLG
3D structure
PDB5mme Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
ChainA
Resolution1.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8Q6 A L1109 P1110 Q1113 V1115 L1120 N1168 V1174 L31 P32 Q35 V37 L42 N90 V96 MOAD: Kd=1.4uM
PDBbind-CN: -logKd/Ki=5.85,Kd=1.4uM
BindingDB: Kd=1400nM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5mme, PDBe:5mme, PDBj:5mme
PDBsum5mme
PubMed30258543
UniProtQ92793|CBP_HUMAN CREB-binding protein (Gene Name=CREBBP)

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