Structure of PDB 5mlj Chain A

Receptor sequence
>5mljA (length=109) Species: 9606 (Homo sapiens) [Search protein sequence]
DPDQLYTTLKNLLAQIKSHPSAWPFMEPVKKSEAPDYYEVIRFPIDLKTM
TERLRSRYYVTRKLFVADLQRVIANCREYNPPDSEYCRCASALEKFFYFK
LKEGGLIDK
3D structure
PDB5mlj Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe.
ChainA
Resolution1.8 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9ST A W751 P752 F753 V757 E761 Y807 N808 Y814 W23 P24 F25 V29 E33 Y79 N80 Y86 MOAD: Ki=1.4nM
PDBbind-CN: -logKd/Ki=8.85,Ki=1.4nM
BindingDB: Ki=1.3nM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:5mlj, PDBe:5mlj, PDBj:5mlj
PDBsum5mlj
PubMed28002667
UniProtQ92830|KAT2A_HUMAN Histone acetyltransferase KAT2A (Gene Name=KAT2A)

[Back to BioLiP]