Structure of PDB 5mlh Chain A

Receptor sequence

>5mlhA (length=364) Species: 29818 (Plantago major) [Search protein sequence]

SSVALIVGVTGIVGNSLAEILPLADTPSGPWKVYGVARRPRPAWNEDNPI
NYIRCDISDPKDTQEKLSPLTDITHVFYVTWANRSTEVERCEANGKMLKN
VLDVVIPNCPDLKHISLQTGRKHYVGPFELIGKIETHDPPFTEDLPRLKF
DNFYYTQEDLLFEEVEKKEGLTWSVHRPGNIFGFSPYSMMNLVGTLCVYA
AICKHEGKVLRFPGCKAAWDGYSDCSDADLIAEHHIWAAVDPYAKNEAFN
VSNGDVFKWKHFWKVLAEQFGVECGEYEEGENLKLQDLMKGKEPVWEEIV
RENGLASTNLEDVAVWWFSDAVLDIPCPLDSMNKSKEHGFLGFRNSKNSF
ISWIDKAKAYKIVP

3D structure

PDB

5mlh A multisubstrate reductase from Plantago major: structure-function in the short chain reductase superfamily.

Chain

Resolution

1.86 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.1.1.145: 3beta-hydroxy-Delta(5)-steroid dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	XOG	A	K147 F153 N205 M215 V347 I350 P351 C352	K122 F128 N180 M190 V322 I325 P326 C327
BS02	NAP	A	G33 T35 G36 I37 A62 R63 R64 C80 D81 I82 T105 W106 Q143 T144 Y179 G204 I206 S213 M214 M215	G8 T10 G11 I12 A37 R38 R39 C55 D56 I57 T80 W81 Q118 T119 Y154 G179 I181 S188 M189 M190
BS03	CA	A	G145 K147 Y179	G120 K122 Y154

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity
GO:0016491	oxidoreductase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors

View graph for
Molecular Function

External links

PDB	RCSB:5mlh, PDBe:5mlh, PDBj:5mlh
PDBsum	5mlh
PubMed	30287897
UniProt	D6N9X1

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