Structure of PDB 5ml0 Chain A

Receptor sequence
>5ml0A (length=108) Species: 10090 (Mus musculus) [Search protein sequence]
PEQLYSTLKNILQQVKNHPNAWPFMEPVKRTEAPGYYEVIRFPMDLKTMS
ERLRNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCASILEKFFFSKI
KEAGLIDK
3D structure
PDB5ml0 Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe.
ChainA
Resolution1.64 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
2.3.1.57: diamine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P2L A P746 F747 E755 Y759 Y801 N802 Y808 P23 F24 E32 Y36 Y78 N79 Y85 PDBbind-CN: -logKd/Ki=6.30,IC50=501nM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:5ml0, PDBe:5ml0, PDBj:5ml0
PDBsum5ml0
PubMed28002667
UniProtQ9JHD1|KAT2B_MOUSE Histone acetyltransferase KAT2B (Gene Name=Kat2b)

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