Structure of PDB 5mkz Chain A

Receptor sequence

>5mkzA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]

SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE

3D structure

PDB

5mkz Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe.

Chain

Resolution

1.62 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	RNK	A	W81 V87 L92 Y139 N140 I146	W40 V46 L51 Y98 N99 I105	MOAD: ic50=20uM PDBbind-CN: -logKd/Ki=4.70,IC50=20uM

External links

PDB	RCSB:5mkz, PDBe:5mkz, PDBj:5mkz
PDBsum	5mkz
PubMed	28002667
UniProt	O60885\|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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