Structure of PDB 5mky Chain A

Receptor sequence
>5mkyA (length=101) Species: 9606 (Homo sapiens) [Search protein sequence]
STPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMK
DKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMM
S
3D structure
PDB5mky Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe.
ChainA
Resolution1.67 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I0D A F44 F45 V49 Y99 N100 Y106 F23 F24 V28 Y78 N79 Y85 MOAD: ic50=2uM
PDBbind-CN: -logKd/Ki=5.70,IC50=2uM
BindingDB: IC50=1995nM
BS02 I0D A L28 F32 M121 L7 F11 M100 MOAD: ic50=2uM
PDBbind-CN: -logKd/Ki=5.70,IC50=2uM
BindingDB: IC50=1995nM
External links
PDB RCSB:5mky, PDBe:5mky, PDBj:5mky
PDBsum5mky
PubMed28002667
UniProtQ9H8M2|BRD9_HUMAN Bromodomain-containing protein 9 (Gene Name=BRD9)

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