Structure of PDB 5mkx Chain A

Receptor sequence
>5mkxA (length=106) Species: 9606 (Homo sapiens) [Search protein sequence]
DQLYSTLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSE
RLKNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCANILEKFFFSKIK
EAGLID
3D structure
PDB5mkx Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe.
ChainA
Resolution1.68 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
2.3.1.57: diamine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 82I A P747 F748 Y802 N803 Y809 P22 F23 Y77 N78 Y84 MOAD: ic50=20uM
PDBbind-CN: -logKd/Ki=4.70,IC50=20uM
BindingDB: IC50=19953nM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:5mkx, PDBe:5mkx, PDBj:5mkx
PDBsum5mkx
PubMed28002667
UniProtQ92831|KAT2B_HUMAN Histone acetyltransferase KAT2B (Gene Name=KAT2B)

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