Structure of PDB 5mku Chain A

Receptor sequence
>5mkuA (length=208) Species: 9606 (Homo sapiens) [Search protein sequence]
DMPVERILEAELAVDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQV
ILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDR
VLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYA
SLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPID
TFLMEMLE
3D structure
PDB5mku Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization.
ChainA
Resolution1.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V280 K284 L294 Q297 V298 R302 F450 E453 V32 K36 L46 Q49 V50 R54 F202 E205
BS02 J57 A I268 A272 N306 F313 R316 L326 A327 C432 L436 I20 A24 N58 F65 R68 L78 A79 C184 L188
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5mku, PDBe:5mku, PDBj:5mku
PDBsum5mku
PubMed28691794
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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