Structure of PDB 5mja Chain A

Receptor sequence
>5mjaA (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]
EFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYS
EKQRRDFLSEASIMGQFDHRNIIRLEGVVTKSRPVMIITEFMENGALDSF
LRQNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVC
KVSDFGLSRYLPTYTSSPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMS
FGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRP
RFAEIVNTLDKMIRNPASLKTVA
3D structure
PDB5mja A Chemical-Genetic Approach to Generate Selective Covalent Inhibitors of Protein Kinases.
ChainA
Resolution2.14 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D744 A746 R748 N749 D762 S781
Catalytic site (residue number reindexed from 1) D136 A138 R140 N141 D154 S167
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7O3 A I625 V633 A649 K651 E668 T697 M700 G703 L751 S761 D762 I17 V25 A41 K43 E60 T89 M92 G95 L143 S153 D154 MOAD: ic50=220nM
PDBbind-CN: -logKd/Ki=6.66,IC50=220nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5mja, PDBe:5mja, PDBj:5mja
PDBsum5mja
PubMed28459525
UniProtP54762|EPHB1_HUMAN Ephrin type-B receptor 1 (Gene Name=EPHB1)

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