Structure of PDB 5mj6 Chain A

Receptor sequence
>5mj6A (length=870) Species: 9606 (Homo sapiens) [Search protein sequence]
NGKLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWN
IILHSTGHNISRVTFMSAVSSQEKQAEILEYAYHGQIAIVAPEALLAGHN
YTLKIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCF
DEPAFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMST
YLVAFIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQN
YFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRK
LVTKIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELS
SYEDFLDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLL
LMLKTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQTLDVKRM
MKTWTLQKGFPLVTVQKKGKELFIQQERFFLNMSYLWHIPLSYVTEGRNY
SKYQSVSLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQ
LKINPYVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPI
TEALFQTDLIYNLLEKLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPS
MRELRSALLEFACTHNLGNCSTTAMKLFDDWMASNGTQSLPTDVMTTVFK
VGAKTDKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSLN
GDNFRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQN
IVAGSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWME
KNLKSLTWWLRTETSQVAPA
3D structure
PDB5mj6 Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity.
ChainA
Resolution2.53 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E431 H464 E465 H468 E487 E541 Y549
Catalytic site (residue number reindexed from 1) E275 H308 E309 H312 E331 E385 Y393
Enzyme Commision number 3.4.11.3: cystinyl aminopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H464 H468 E487 H308 H312 E331
BS02 7O2 A E295 G428 A429 M430 E431 L457 I461 H464 E465 H468 E487 Y549 F550 Y961 E139 G272 A273 M274 E275 L301 I305 H308 E309 H312 E331 Y393 F394 Y796 BindingDB: IC50=32nM,Ki=18nM
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5mj6, PDBe:5mj6, PDBj:5mj6
PDBsum5mj6
PubMed28328206
UniProtQ9UIQ6|LCAP_HUMAN Leucyl-cystinyl aminopeptidase (Gene Name=LNPEP)

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