Structure of PDB 5miv Chain A

Receptor sequence

>5mivA (length=442) Species: 10090 (Mus musculus)

PSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKE
LWFSDDPNVTKTLQFRQWNGKERSIYFQPPSFYVSAQDLPNIENGGVAVL
TGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAIDRAGAEVK
SRTTLFRKIGDFRALEKISREVKSITVIGEGFLGSELACALGRKSQASGI
EVIQLFPEKGNMGKILPQYLSNWTMEKVKREGVKVMPNAIVQSVGVSGGR
LLIKLKDGRKVETDHIVTAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQ
ARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWH
QSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKEITIPEDYGKGVIFYLRD
KVVVGIVLWNVFNRMPIARKIIKDGEQHEDLNEVAKLFNIHE

3D structure

• PDB: 5miv Structural bases of the altered catalytic properties of a pathogenic variant of apoptosis inducing factor.
• Chain: A
• Resolution: 3.1 Å

Enzymatic activity

• Enzyme Commision number: 1.6.99.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	A	E307 G308 F309 L310 E313 P334 V397 G398 E452 H453 W482	E180 G181 F182 L183 E186 P207 V270 G271 E325 H326 W355
BS02	FAD	A	G137 G138 T140 A141 V161 E163 R171 P172 S175 V232 T259 G260 R284 G436 D437 H453 H454 A457 W482	G10 G11 T13 A14 V34 E36 R44 P45 S48 V105 T132 G133 R157 G309 D310 H326 H327 A330 W355

Gene Ontology

Molecular Function

• GO:0016491 oxidoreductase activity
• GO:0046983 protein dimerization activity

External links

• PDB: RCSB:5miv, PDBe:5miv, PDBj:5miv
• PDBsum: 5miv
• PubMed: 28666871
• UniProt: Q9Z0X1|AIFM1_MOUSE Apoptosis-inducing factor 1, mitochondrial (Gene Name=Aifm1)