Structure of PDB 5mho Chain A

Receptor sequence
>5mhoA (length=678) Species: 9606 (Homo sapiens) [Search protein sequence]
PPNNSNAAEDDLPTVELQGVVPRGVNLQEFLNVTSVHLFKERWDTNKVDH
HTDKYENNKLIVRRGQSFYVQIDFSRPYDPRRDLFRVEYVIGRYPQENKG
TYIPVPIVSELQSGKWGAKIVMREDRSVRLSIQSSPKCIVGKFRMYVAVW
TPYGVLRTSRNPETDTYILFNPWCEDDAVYLDNEKEREEYVLNDIGVIFY
GEVNDIKTRSWSYGQFEDGILDTCLYVMDRAQMDLSGRGNPIKVSRVGSA
MVNAKDDEGVLVGSWDNIYAYGVPPSAWTGSVDILLEYRSSENPVRYGQC
WVFAGVFNTFLRCLGIPARIVTNYFSAHDNDANLQMDIFVNSKLTKDSVW
NYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAIKHG
HVCFQFDAPFVFAEVNSDLIYIHVVENVDATHIGKLIVTKQIGGDGMMDI
TDTYKFQEGQEEERLALETALMYSNVDMDFEVENAVLGKDFKLSITFRNN
SHNRYTITAYLSANITFYTGVPKAEFKKETFDVTLEPLSFKKEAVLIQAG
EYMGQLLEQASLHFFVTARINETRDVLAKQKSTVLTIPEIIIKVRGTQVV
GSDMTVIVEFTNPLKETLRNVWVHLDGPGVTRPMKKMFREIRPNSTVQWE
EVCRPRKLIASMSSDSLRHVYGELDVQI
3D structure
PDB5mho Structure of active coagulation factor XIII triggered by calcium binding: basis for the design of next-generation anticoagulants.
ChainA
Resolution2.92 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) W279 C314 H373 D396 Y560
Catalytic site (residue number reindexed from 1) W265 C300 H353 D376 Y518
Enzyme Commision number 2.3.2.13: protein-glutamine gamma-glutamyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y214 W279 C314 I352 D367 V369 W370 N371 Y372 H373 Q400 Y200 W265 C300 I338 D347 V349 W350 N351 Y352 H353 Q380
BS02 CA A A264 N267 K269 D270 D271 A250 N253 K255 D256 D257
BS03 CA A D343 D345 N347 Q349 D351 D367 D329 D331 N333 Q335 D337 D347
BS04 CA A N436 A457 E485 N416 A430 E458
Gene Ontology
Molecular Function
GO:0003810 protein-glutamine gamma-glutamyltransferase activity
GO:0005515 protein binding
GO:0016746 acyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0007596 blood coagulation
GO:0018149 peptide cross-linking
GO:0072378 blood coagulation, fibrin clot formation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0031093 platelet alpha granule lumen
GO:0062023 collagen-containing extracellular matrix
GO:0072562 blood microparticle
GO:1990234 transferase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5mho, PDBe:5mho, PDBj:5mho
PDBsum5mho
PubMed
UniProtP00488|F13A_HUMAN Coagulation factor XIII A chain (Gene Name=F13A1)

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