Structure of PDB 5mhk Chain A

Receptor sequence
>5mhkA (length=186) Species: 10298 (Human alphaherpesvirus 1) [Search protein sequence]
GAFYARYRDGYVSGEPWPGAGPPPPGRVLYGGLGDSRPGLWGAPEAEEAR
RRFEASGAPAAVWAPELGDAAQQYALITRLLYTPDAEAMGWLQNPRVVPG
DVALDQACFRISGAARNSSSFITGSVARAVPHLGYAMAAGRFGWGLAHAA
AAVAMSRRYDRAQKGFLLTSLRRAYAPLLARENAAL
3D structure
PDB5mhk The herpes viral transcription factor ICP4 forms a novel DNA recognition complex.
ChainA
Resolution2.28 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R307 D308 V311 S312 R480 R8 D9 V12 S13 R181 PDBbind-CN: Kd=1.6nM
BS02 dna A A304 R305 A5 R6 PDBbind-CN: Kd=1.6nM
BS03 dna A R415 S419 R460 R116 S120 R161 PDBbind-CN: Kd=1.6nM
BS04 dna A S418 R456 R457 S119 R157 R158 PDBbind-CN: Kd=1.6nM
Gene Ontology
Biological Process
GO:0045893 positive regulation of DNA-templated transcription

View graph for
Biological Process
External links
PDB RCSB:5mhk, PDBe:5mhk, PDBj:5mhk
PDBsum5mhk
PubMed28505309
UniProtP08392|ICP4_HHV11 Major viral transcription factor ICP4 (Gene Name=ICP4)

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