Structure of PDB 5mh5 Chain A

Receptor sequence

>5mh5A (length=308) Species: 523841 (Haloferax mediterranei ATCC 33500) [Search protein sequence]

MHIERLAVDESVGRAMPPQRFIEALSDLGVPVEFAGEDEQFGPGDAVASF
GHRDAFLDADWVHCIRAGYDEFPVGVYEEAGTYLTNSTGIHGTTVGETVA
GYMLTFARRLHAYRDAQHDHAWDLPRYEEPFTLAGERVCVVGLGTLGRGV
VDRAAALGMEVVGVRRSGDPVDNVSTVYTPDRLHEAIADARFVVLATPLT
DETEGMVAAPEFETMREDASLVNVARGPVVVESDLVAALDSGDIAGAALD
VFSEEPLPEDSPLWDFEDVLITPHVSAATSKYHEDVAALIRENIEKIATG
DELTNRVV

3D structure

PDB

5mh5 Productive ternary complexes of D-2-hydroxyacid dehydrogenase provide insights into the chiral specificity of its reaction mechanism

Chain

Resolution

1.4 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.1.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	MG	A	T132 A134	T132 A134
BS02	MG	A	F212 E213 M215 D243	F212 E213 M215 D243
BS03	7N5	A	R66 A67 G68 H91 R226 H274 Y282	R66 A67 G68 H91 R226 H274 Y282
BS04	NAP	A	A67 G68 T88 G142 L143 G144 T145 L146 R165 R166 S167 T197 P198 T203 V224 A225 R226 H274 S276	A67 G68 T88 G142 L143 G144 T145 L146 R165 R166 S167 T197 P198 T203 V224 A225 R226 H274 S276

Gene Ontology

	Molecular Function
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0031406	carboxylic acid binding
GO:0051287	NAD binding
GO:0070402	NADPH binding
GO:0070404	NADH binding

	Biological Process
GO:0019752	carboxylic acid metabolic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:5mh5, PDBe:5mh5, PDBj:5mh5
PDBsum	5mh5
PubMed
UniProt	Q2VEQ7\|DDH_HALMT D-2-hydroxyacid dehydrogenase (Gene Name=ddh)

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