Structure of PDB 5mfz Chain A

Receptor sequence

>5mfzA (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]

PFTADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTAS
GIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRF
LVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGL
KATGRLCTVACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTS
LQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLM
KHLGLEIPAWDGPRVLERALPPLPRPPTPKLE

3D structure

PDB

5mfz Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules.

Chain

Resolution

2.1 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	P62 D63 F64 R65 N114 D116 H133
Catalytic site (residue number reindexed from 1)	P53 D54 F55 R56 N105 D107 H124
Enzyme Commision number	2.3.1.- 2.3.1.286: protein acetyllysine N-acetyltransferase. 2.4.2.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	AR6	A	G52 A53 G54 T57 D63 F64 R65 Q113 H133 G214 T215 S216 I219 N240 L241 Q242 G256 Y257 V258	G43 A44 G45 T48 D54 F55 R56 Q104 H124 G198 T199 S200 I203 N224 L225 Q226 G240 Y241 V242
BS02	ZN	A	C141 C144 C166 C177	C132 C135 C157 C161
BS03	7M9	A	P62 F64 V70 W71 F86 V115	P53 F55 V61 W62 F77 V106

Gene Ontology

	Molecular Function
GO:0070403	NAD+ binding

View graph for
Molecular Function

External links

PDB	RCSB:5mfz, PDBe:5mfz, PDBj:5mfz
PDBsum	5mfz
PubMed	27990725
UniProt	Q8N6T7\|SIR6_HUMAN NAD-dependent protein deacylase sirtuin-6 (Gene Name=SIRT6)

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