Structure of PDB 5mfx Chain A

Receptor sequence
>5mfxA (length=434) Species: 64320 (Zika virus) [Search protein sequence]
MLKKKQLTVLDLHPGAGKTRRVLPEIVREAIKTRLRTVILAPTRVVAAEM
EEALRGLPVRYMTTAVNVTHSGTEIVDLMCHATFTSRLLQPIRVPNYNLY
IMDEAHFTDPSSIAARGYISTRVEMGEAAAIFMTATPPGTRDAFPDSNSP
IMDTEVEVPERAWSSGFDWVTDYSGKTVWFVPSVRNGNEIAACLTKAGKR
VIQLSRKTFETEFQKTKHQEWDFVVTTDISEMGANFKADRVIDSRRCLKP
VILDGERVILAGPMPVTHASAAQRRGRIGRNPNKPGDEYLYGGGCAETDE
DHAHWLEARMLLDNIYLQDGLIASLYRPEADKVAAIEGEFKLRTEQRKTF
VELMKRGDLPVWLAYQVASAGITYTDRRWCFDGTTNNTIMEDSVPAEVWT
RHGEKRVLKPRWMDARVCSDHAALKSFKEFAAGK
3D structure
PDB5mfx How Zika virus NS3 helicase grips the first nucleotide of the leading RNA strand
ChainA
Resolution1.598 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A T225 R226 T245 C262 A264 T265 D291 S365 V366 S387 R388 T409 D410 I411 L430 D540 R598 T43 R44 T63 C80 A82 T83 D109 S183 V184 S205 R206 T227 D228 I229 L248 D358 R416
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:5mfx, PDBe:5mfx, PDBj:5mfx
PDBsum5mfx
PubMed
UniProtA0A146CJH9

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