Structure of PDB 5mfv Chain A

Receptor sequence
>5mfvA (length=250) Species: 10116 (Rattus norvegicus) [Search protein sequence]
RTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDV
KLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSK
PFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKIST
YEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCN
LTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRG
3D structure
PDB5mfv Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors.
ChainA
Resolution2.181 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5PX A K531 P532 F533 M534 T535 Q786 K100 P101 F102 M103 T104 Q235
BS02 5PX A P532 T535 K762 G763 P101 T104 K211 G212
BS03 KAI A E441 Y489 P516 T518 R523 G688 S689 T690 E738 E10 Y58 P85 T87 R92 G137 S138 T139 E187 BindingDB: IC50=77nM,Ki=75.9nM,EC50=37000nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:5mfv, PDBe:5mfv, PDBj:5mfv
PDBsum5mfv
PubMed28360094
UniProtP22756|GRIK1_RAT Glutamate receptor ionotropic, kainate 1 (Gene Name=Grik1)

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