Structure of PDB 5mfe Chain A

Receptor sequence

>5mfeA (length=281) Species: 32630 (synthetic construct) [Search protein sequence]

ELPQMVQQLNSPDQQELQSALRKLSQIASGGNEQIQAVIDAGALPALVQL
LSSPNEQILQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQI
LQEALWALSNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWAL
SNIASGGNEQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGN
EQIQAVIDAGALPALVQLLSSPNEQILQEALWALSNIASGGNEQKQAVKE
AGALEKLEQLQSHENEKIQKEAQEALEKLQS

3D structure

PDB

5mfe Curvature of designed armadillo repeat proteins allows modular peptide binding.

Chain

Resolution

1.95 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	R33 Q37 E72 W75 N79 S82 G83 G84 N85 W117 S120 N121 S124 E156 W159 N163 W201	R22 Q26 E61 W64 N68 S71 G72 G73 N74 W106 S109 N110 S113 E145 W148 N152 W190
BS02	CA	A	P65 E67	P54 E56
BS03	CA	A	P149 E151	P138 E140
BS04	CA	A	P191 E193	P180 E182
BS05	CA	A	P233 E235	P222 E224
BS06	CA	A	P107 E109	P96 E98
BS07	CA	A	P23 Q25	P12 Q14

External links

PDB	RCSB:5mfe, PDBe:5mfe, PDBj:5mfe
PDBsum	5mfe
PubMed	28864298

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