Structure of PDB 5mez Chain A

Receptor sequence
>5mezA (length=125) Species: 9606 (Homo sapiens) [Search protein sequence]
ACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITTN
GAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKY
CQYAFDLKCDSVCVNPYHYERVVSP
3D structure
PDB5mez Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors.
ChainA
Resolution2.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R38 T77 L78 L82 Q83 K88 R24 T63 L64 L68 Q69 K74 PDBbind-CN: Kd=250nM
BS02 ZN A C71 C115 C127 H132 C57 C101 C113 H118
Gene Ontology
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005667 transcription regulator complex

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Biological Process
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Cellular Component
External links
PDB RCSB:5mez, PDBe:5mez, PDBj:5mez
PDBsum5mez
PubMed29234012
UniProtQ13485|SMAD4_HUMAN Mothers against decapentaplegic homolog 4 (Gene Name=SMAD4)

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