Structure of PDB 5mev Chain A

Receptor sequence
>5mevA (length=151) Species: 9606,10090 [Search protein sequence]
DDLYRQSLEIISRYLREQATGSKDSKPLGEAGAAGRRALETLRRVGDGVQ
RNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFG
AFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV
E
3D structure
PDB5mev Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors
ChainA
Resolution2.94 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7LW A H224 A227 M231 H252 V253 R263 T266 F270 H53 A56 M60 H81 V82 R92 T95 F99 PDBbind-CN: -logKd/Ki=7.00,Kd=0.1uM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:5mev, PDBe:5mev, PDBj:5mev
PDBsum5mev
PubMed28197319
UniProtP97287|MCL1_MOUSE Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Gene Name=Mcl1);
Q07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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