Structure of PDB 5mes Chain A

Receptor sequence
>5mesA (length=151) Species: 9606,10090 [Search protein sequence]
DDLYRQSLEIISRYLREQATGSKDSKPLGEAGAAGRRALETLRRVGDGVQ
RNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFG
AFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV
E
3D structure
PDB5mes Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors.
ChainA
Resolution2.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7LT A H224 M231 L246 V249 M250 H252 V253 R263 T266 L267 F270 G271 H53 M60 L75 V78 M79 H81 V82 R92 T95 L96 F99 G100 MOAD: Kd=0.34uM
PDBbind-CN: -logKd/Ki=6.47,Kd=0.34uM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:5mes, PDBe:5mes, PDBj:5mes
PDBsum5mes
PubMed28197319
UniProtP97287|MCL1_MOUSE Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Gene Name=Mcl1);
Q07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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